Postdoctoral Associate – 3D Chromatin Genomics
JAX 4D Nucleome Center | Supervisor: Dr. Chia-Lin Wei
About JAX-GM: Comprising 183,000 square feet of highly advanced, state-of-the-art laboratories and supporting facilities, the brand new JAX-GM conveniently sits midway between NYC and Boston in the heart of Connecticut. JAX-GM is part of an exciting $1.1 billion venture between the state of Connecticut and The Jackson Laboratory, an internationally-recognized research and educational institution with unparalleled genomic resources and research support services.
About the JAX 4D Nucleome Center: Investigators at the JAX 4D Nucleome Center at JAX-GM have pioneered technologies for the genome-wide profiling of chromatin interactions. Although the genome is typically thought of as a linear sequence, it is actually a dynamic three-dimensional structure. Gene loci and regulatory elements that are linearly distant—or even on separate chromosomes—may be brought in spatial proximity, and such interactions are of fundamental importance for understanding genome regulation. The ultimate goal of the JAX 4D Nucleome Center is to deliver a Nucleome Positioning System for the generation of complex chromatin interaction network maps in the context of 3D genome structures. Such maps will be used to monitor and reference the dynamics of individual genomic elements, providing context to better understand gene function and the effects of genetic variation on gene function. The scientific team is led by Yijun Ruan, Chia-Lin Wei, Jeff Chuang, and Duygu Ucar.
About the position: The JAX 4D Nucleome Center is seeking enthusiastic, highly-skilled computational and experimental postdocs to develop computational and genomic approaches for understanding 3D genome biology under the light of diverse genomic and genetic information. Working under the supervision of Principal Investigator Chia-Lin Wei, successful applicants to this position will be developing projects aligned with Dr. Wei’s research focus. For details about Dr. Wei’s areas of focus, visit her Faculty page.
The Center’s postdoctoral researchers will be generating and analyzing human chromatin interaction datasets in integration with other genomics and genetics datasets. We are seeking self-motivated, independent individuals who are interested in building their own career paths; however, postdoctoral fellows are expected to coordinate with and report to the PI responsible for the research areas addressed by their project.
The fellows will develop research projects in one or more areas of focus:
- 3D genome mapping and imaging technologies
- Application of nano-engineering toward genomic methodologies
- Computational modeling of 3D genome architectures
- Building regulatory networks at multiple layers including gene expression, epigenetic, and chromatin data
- Integrating regulatory interactions with genetic data
- Mining and aligning chromatin interaction datasets in diverse human cell types
- Functional perturbation of topological elements
REQUIRED SKILLS & QUALIFICATIONS
The JAX 4D Nucleome Center is interdisciplinary and collaborative, and preference will be given to individuals with experience working in such an environment.
For computational postdocs desired attributes include:
- Familiarity with next generation sequencing data sets and pre-processing
- PhD in a statistics/biostatistics or another computational field (CS, EE, Physics) with a strong foundation in statistics and data analyses
- Excellent programming skills, preferentially with expertise in R and/or python and UNIX programming
- Familiarity with network building, mining, alignment algorithms
- Familiarity with bioinformatics resources, i.e., UCSC genome browser, NCBI
For experimental postdocs desired attributes include:
- Strong problem-solving skills, creative thinking, and enthusiastic about science
- Familiarity with next generation sequencing data sets and data generation
- PhD in a genomics/genetics/biology or another relevant field
- Excellent communication skills and fully fluent spoken and written English
- Expertise in cellular and molecular biology techniques
MORE ABOUT JAX
JAX began in 1929 with a small group of scientists dedicated to the emerging field of genetics. We now have over 1700 scientists, technicians, and support staff, including over 50 Principle Investigators in five primary disease areas: cancer, reproductive biology, immunology, metabolic processes, and neuroscience. Our fundamental contributions to biomedical research include cancer genetics and establishing the mouse as the premier research animal model.
- Uncover more of our historic milestones, including the 26 Nobel prizes associated with our research, resources, & education
- Read our latest news & insights for a glimpse at how we’re impacting the future of biomedicine
- Follow the progress we’re making on our quest to improve human health via our recent research highlights
EEO: All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.