Postdoctoral Associate 3D Chromatin Genomics - Wei Lab
The Jackson Laboratory | Farmington, CT
Postdoctoral Associate – 3D Chromatin Genomics
JAX 4D Nucleome Center | Supervisor: Dr. Chia-Lin Wei
The JAX 4D Nucleome Center is seeking enthusiastic, highly-skilled computational and experimental postdocs to develop computational and genomic approaches for understanding 3D genome biology under the light of diverse genomic and genetic information. Working under the supervision of Principal Investigator Chia-Lin Wei, successful applicants to this position will be developing projects aligned with Dr. Wei’s research focus. For details about Dr. Wei’s areas of focus, visit her Faculty page.
About the JAX 4D Nucleome Center: Investigators at the JAX 4D Nucleome Center at JAX-GM have pioneered technologies for the genome-wide profiling of chromatin interactions. Although the genome is typically thought of as a linear sequence, it is actually a dynamic three-dimensional structure. Gene loci and regulatory elements that are linearly distant—or even on separate chromosomes—may be brought in spatial proximity, and such interactions are of fundamental importance for understanding genome regulation. The ultimate goal of the JAX 4D Nucleome Center is to deliver a Nucleome Positioning System for the generation of complex chromatin interaction network maps in the context of 3D genome structures. Such maps will be used to monitor and reference the dynamics of individual genomic elements, providing context to better understand gene function and the effects of genetic variation on gene function. The scientific team is led by Yijun Ruan, Chia-Lin Wei, Jeff Chuang, and Duygu Ucar.
The Center’s postdoctoral researchers will be generating and analyzing human chromatin interaction datasets in integration with other genomics and genetics datasets. We are seeking self-motivated, independent individuals who are interested in building their own career paths; however, postdoctoral fellows are expected to coordinate with and report to the PI responsible for the research areas addressed by their project.
The fellows will develop research projects in one or more areas of focus:
- 3D genome mapping and imaging technologies
- Application of nano-engineering toward genomic methodologies
- Computational modeling of 3D genome architectures
- Building regulatory networks at multiple layers including gene expression, epigenetic, and chromatin data
- Integrating regulatory interactions with genetic data
- Mining and aligning chromatin interaction datasets in diverse human cell types
- Functional perturbation of topological elements
The JAX 4D Nucleome Center is interdisciplinary and collaborative, and preference will be given to individuals with experience working in such an environment.
For computational postdocs desired attributes include:
- Familiarity with next generation sequencing data sets and pre-processing
- PhD in a statistics/biostatistics or another computational field (CS, EE, Physics) with a strong foundation in statistics and data analyses
- Excellent programming skills, preferentially with expertise in R and/or python and UNIX programming
- Familiarity with network building, mining, alignment algorithms
- Familiarity with bioinformatics resources, i.e., UCSC genome browser, NCBI
For experimental postdocs desired attributes include:
- Strong problem-solving skills, creative thinking, and enthusiastic about science
- Familiarity with next generation sequencing data sets and data generation
- PhD in a genomics/genetics/biology or another relevant field
- Excellent communication skills and fully fluent spoken and written English
- Expertise in cellular and molecular biology techniques
The Jackson Laboratory (www.jax.org) is a nonprofit biomedical research institute with over 1,800 employees across three campuses nationwide. Our mission is to discover precise genomic solutions for human disease, and to empower the global biomedical community in the shared quest to improve human health. JAX's research institute in Connecticut, The Jackson Laboratory for Genomic Medicine (JAX-GM), is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX-GM’s research focuses on the complex genetic causes of disease, and on the development of genomic solutions tailored to each person's unique genetic makeup.
JAX-GM sits on a 17-acre site on the campus of the University of Connecticut Health Center. The 183,500-square-foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians and support staff in state-of-the-art computing facilities and laboratories. Our employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients’ lives.
JAX-GM resides in the scenic town of Farmington, in the state’s capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns. JAX-GM is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems including bus lines, highways, railroads and international airports.
INTEGRITY - Courage and commitment to do what is right
PEOPLE - Inspiring our people to enhance the health of all
ONE TEAM - Unified by our promise to transform medicine and science
EXCELLENCE - Achieving world-class results
INNOVATION - Leading with discovery and creative solutions
STEWARDSHIP - Caring for and enhancing the resources entrusted to us
What do we have to offer?
JAX offers a dynamic and supportive work environment, competitive salaries and a comprehensive benefits package including a medical plan, outstanding retirement plan, generous paid time off and tuition reimbursement. JAX offers an MBA program, a fitness center with an award winning wellness program, and a fully operational primary care facility available to employees and their families.
Most importantly, every position contributes to JAX’s mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health.
The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.
Learn more about at opportunities at JAX at http://www.jax.org/careers